Neuroscience Graduate Program at UCSF
Neurovascular Mechanisms of Inflammation and Tissue Repair
Our lab studies mechanisms of neurovascular regulation of inflammation and tissue repair. Our current research focuses on identifying the molecular and cellular interface that blood proteins utilize to interact with nervous system cells and change their functions. Our ultimate goal is to target these interactions for therapeutic intervention in neurologic diseases.
Rupture of the vasculature allows the entry of blood proteins into the brain with subsequent edema formation and neuronal damage in a variety of neurologic diseases, such as stroke, multiple sclerosis (MS), Alzheimer's Disease (AD) and spinal cord injury. Our studies aim to unravel the molecular mechanisms of the CNS response to neurovascular changes with the ultimate goal to develop novel therapeutic strategies for neurologic diseases.
We integrate animal modeling, histopathology, tissue culture and biochemistry techniques, as a multifaceted experimental approach to address the biological complexity of disease and repair mechanisms. We have developed in vivo imaging tools of the mouse brain and spinal cord that enable us to monitor disease processes in real time in the living animal.
Kim Baeten, Ph.D., Postdoctoral Fellow
Bernat Baeza-Raja, Ph.D., Postdoctoral Fellow
Catherine Bedard, M.Sc., Research Associate
Dimitrios Davalos, Ph.D., Staff Research Scientist
Tracey Dunitz, Administrative Assistant
Natacha Le Moan, Ph.D., Postdoctoral Fellow
Mario Merlini, Ph.D., Postdoctoral Fellow
Mark Petersen, M.D., Medical Fellow
Jae Kyu Ryu, Ph.D., Postdoctoral Fellow
Eirini Vagena, Graduate Student
Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. PNAS, 2012. 109:5838-43.
Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K. Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1 alpha. Mol Cell, 2011. 44:476-90.
Schachtrup C, Ryu JK, Helmrick M, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting availability of active TGFβ after vascular damage. J Neurosci, 2010. 30:5843-54.
Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG & Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature, 2008. 453:807-11.
Davalos D, Lee JK, Brinkman B, Zheng B, Akassoglou K. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods, 2008. 169:1-7. Selected for Cover
Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: Lessons from multiple sclerosis. Curr Med Chem, 2007, 14:2925-36.
Schachtrup C, Lu P, Lee JK, Jones L, Sachs BD, Ju J, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated transactivation of the EGF receptor. Proc Natl Acad Scie USA, 2007. 104:11814-19.
Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol, 2007. 177:1119-32.
Passino MA, Adams, RA, Sikorski SL, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science, 2007. 315:1853-56
Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease. J Exp Med, 2007. 204:571-582. Selected for Cover
Katerina Akassoglou, Ph.D.
Gladstone Institute of Neurological Disease
1650 Owens Street, room 312
San Francisco, CA 94158