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Neuroscience Graduate Program at UCSF

NS219 - Topics in Basic or Translational Neuroscience
(Mini Course)

MicroRNAs in Neuronal Development and Function

Course Directors:
Michael McManus, email: mmcmanus@diabetes.ucsf.edu
Fen-Biao Gao, email: fgao@gladston.ucsf.edu
Erik Ullian, email: ulliane@vision.ucsf.edu

First Class: Monday, March 30, 2009
See below for class schedule and locations.

Course Description:
MicroRNAs are endogenous, noncoding small RNAs that regulate gene expression by destabilizing target mRNAs or suppressing their translation. Hundreds of miRNAs have been identified in worms, flies, and humans, and many are evolutionarily conserved at the nucleotide level. Some miRNAs are specifically expressed in developing and mature nervous systems, and their roles in neuronal development and function have begun to be unraveled. In this minicourse, Basic concepts relevant to the topic will be presented and active participation from students is expected to discuss the latest publications in this area.

Class Roster:

Name: Program:
Lipinski, Joanna  BMI
Rollins, Geoff BMI
Ho, Linh CCB
Myers, Samuel CCB
Bagley, Josh   NS
Gertz, Caitlyn   NS
Korb, Erica   NS
Locke, Cody  NS
Lovero, Kate  NS
Markenscoff-Papadimitriou, Eirene  NS
Silberberg, Shanni  NS
Tien, Jason NS

For your study list please use:
NS 219, 3 units, Director: Fen-Biao Gao, Grade option: S/U.

Class Schedule:
PH-Parnassus
MB-Mission Bay

Date
Time
Location
Class Topic
Course Instructor
Monday, 3/30/2009
10am-12pm
PH S170
Introduction to small RNAs
Michael McManus
Wed., 4/1/2009
10am-12pm
PH S170
Mechanisms of action
Michael McManus
Monday, 4/6/2009
10am-12pm
PH S170
Small RNA biology and Tools
Michael McManus
Tuesday, 4/7/2009
10am-12pm
MB--Gladstone 101A
MicroRNAs in Stem Cells/Neural Progenitors
Fen-Biao Gao
Wed., 4/8/2009
2pm-4pm
MB--Gladstone 101A
MicroRNAs in neuronal morphogenesis
Fen-Biao Gao
Friday, 4/10/2009
10am-12pm
MB--Gladstone 101C
MicroRNAs in neurodegeneration
Fen-Biao Gao
Monday, 4/13/09
10am-12pm
PH S170
MicroRNA Regulation of Neuronal
Erik Ullian
Wed., 4/15/2009
10am-12pm
PH S170
Translational Regulation of Plasticity
Erik Ullian
Friday, 4/17/2009
10am-12pm
PH S170
MircoRNA Regulation of Synaptic
Erik Ullian

Courses


Course Materials
(UCSF Access only)

3/30/09
Lee RC, et. al. Cell 1993. 75:843-54

4/1/09

4/6/09
Fire A, et. al. Nature 1998. 391:806-11

4/7/09
Tay Y, et. al. Nature. 455:1124-1128 (2 students)

Leucht, C, et. al. Nature Neuroscience. 2008 11(6):641-648(2 students)
Supplemental materials

4/8/09
Wayman GA, et. al. PNAS. 105:9093-9098 (2 students)

Fiore R, et. al. EMBO J. 2009 Feb. 5. (2 students)

4/10/09
Karres JS, et. al. Cell. 131:136-145 (2 students)

Schaefer A, et al. J. Exp. Med. 204:1553-1558 (1 student)

Lee Y, et. al. Nat. Neurosci. 11:1137-1139 (1 student)

4/13/09
Cheng, HYM, et. al. Neuron. 54:813-829

Kocerha J, et. al. PNAS. 106(9):3507-3512

4/15/09
Park, CS, et. al. J. Mol. Neurosci. 2008

Cougot, N, et.al. J. Neurosci. 2008. 28(51):13793-13804

4/17/09
Schratt, GM. et. al. Nature. 2006. 439:283-289

Simon, DJ. et. al. Cell. 2008. 133:903-915