Neuroscience Graduate Program at UCSF
NS219 - Topics in Basic or Translational Neuroscience
(Mini Course)
MicroRNAs in Neuronal Development and Function
Course Directors:
Michael McManus, email: mmcmanus@diabetes.ucsf.edu
Fen-Biao Gao, email: fgao@gladston.ucsf.edu
Erik Ullian, email: ulliane@vision.ucsf.edu
First Class: Monday, March 30, 2009
See below for class schedule and locations.
Course Description:
MicroRNAs are endogenous, noncoding small RNAs that regulate gene expression by destabilizing target mRNAs or suppressing their translation. Hundreds of miRNAs have been identified in worms, flies, and humans, and many are evolutionarily conserved at the nucleotide level. Some miRNAs are specifically expressed in developing and mature nervous systems, and their roles in neuronal development and function have begun to be unraveled. In this minicourse, Basic concepts relevant to the topic will be presented and active participation from students is expected to discuss the latest publications in this area.
Class Roster:
| Name: | Program: |
| Lipinski, Joanna | BMI |
| Rollins, Geoff | BMI |
| Ho, Linh | CCB |
| Myers, Samuel | CCB |
| Bagley, Josh | NS |
| Gertz, Caitlyn | NS |
| Korb, Erica | NS |
| Locke, Cody | NS |
| Lovero, Kate | NS |
| Markenscoff-Papadimitriou, Eirene | NS |
| Silberberg, Shanni | NS |
| Tien, Jason | NS |
For your study list please use:
NS 219, 3 units, Director: Fen-Biao Gao, Grade option: S/U.
Class Schedule:
PH-Parnassus
MB-Mission Bay
Date |
Time |
Location |
Class Topic |
Course Instructor |
Monday, 3/30/2009 |
10am-12pm |
PH S170 |
Introduction to small RNAs |
Michael McManus |
Wed., 4/1/2009 |
10am-12pm |
PH S170 |
Mechanisms of action |
Michael McManus |
Monday, 4/6/2009 |
10am-12pm |
PH S170 |
Small RNA biology and Tools |
Michael McManus |
Tuesday, 4/7/2009 |
10am-12pm |
MB--Gladstone 101A |
MicroRNAs in Stem Cells/Neural Progenitors |
Fen-Biao Gao |
Wed., 4/8/2009 |
2pm-4pm |
MB--Gladstone 101A |
MicroRNAs in neuronal morphogenesis |
Fen-Biao Gao |
Friday, 4/10/2009 |
10am-12pm |
MB--Gladstone 101C |
MicroRNAs in neurodegeneration |
Fen-Biao Gao |
Monday, 4/13/09 |
10am-12pm |
PH S170 |
MicroRNA Regulation of Neuronal |
Erik Ullian |
Wed., 4/15/2009 |
10am-12pm |
PH S170 |
Translational Regulation of Plasticity |
Erik Ullian |
Friday, 4/17/2009 |
10am-12pm |
PH S170 |
MircoRNA Regulation of Synaptic |
Erik Ullian |
Courses
Course Materials
(UCSF Access only)
3/30/09
Lee RC, et. al. Cell 1993. 75:843-54
4/1/09
4/6/09
Fire A, et. al. Nature 1998. 391:806-11
4/7/09
Tay Y, et. al. Nature. 455:1124-1128 (2 students)
Leucht, C, et. al. Nature Neuroscience. 2008 11(6):641-648(2 students)
Supplemental materials
4/8/09
Wayman GA, et. al. PNAS. 105:9093-9098 (2 students)
Fiore R, et. al. EMBO J. 2009 Feb. 5. (2 students)
4/10/09
Karres JS, et. al. Cell. 131:136-145 (2 students)
Schaefer A, et al. J. Exp. Med. 204:1553-1558 (1 student)
Lee Y, et. al. Nat. Neurosci. 11:1137-1139 (1 student)
4/13/09
Cheng, HYM, et. al. Neuron. 54:813-829
Kocerha J, et. al. PNAS. 106(9):3507-3512
4/15/09
Park, CS, et. al. J. Mol. Neurosci. 2008
Cougot, N, et.al. J. Neurosci. 2008. 28(51):13793-13804
4/17/09
Schratt, GM. et. al. Nature. 2006. 439:283-289
Simon, DJ. et. al. Cell. 2008. 133:903-915