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Neuroscience Graduate Program at UCSF

NS219 - Topics in Basic or Translational Neuroscience
(Mini Course)

Fronto-Temporal Dementia

Course Directors:
Bob Farese, email: bfarese@gladstone.ucsf.edu
Aimee Kao, email: aimeekao@gmail.com

First Class: Monday, April 20, 2009
See below for class schedule and locations.

Course Description:
This minicourse will explore the biology of frontotemporal dementia (FTD). FTD is the most common neurodegenerative disease in people under the age of 65, accounting for 15–20% of all dementia cases. This devastating disease is rapidly progressive and characterized by progressive neurodegeneration in the frontal and temporal lobes, often resulting in dramatic changes in behavior and personality. Insights into the molecular, cellular, and genetic bases of FTD are rapidly emerging. This course will cover broad aspects of FTD, ranging from the basic biology underlying the disease to clinical aspects, including ideas and approaches for therapies. The format will combine brief overview lectures, paper discussions, and the development of a brief and focused research plan.

Class Roster:

Name Program:
Newman, Heather BMI
Varela, Rocco  BMI
Freeze, Ben  BMS
Petty, Lamar  CCB
Langseth, Abe  NS
Larkin, Paul  NS
Shen, Helen  NS
Moon, NyangMi "Amy" BMS
Krater, Ian BMS
Sahai, Pankaj BMS
Chege, Sally NS

For your study list please use:
NS 219, 3 units, Director: Louis Reichardt, Grade option: S/U.

Class Schedule:
MB-Mission Bay

Date
Time
Location
Class Topic
Course Instructor
Monday, 4/20/2009
10-Noon
MB GH S261
Introduction to FTD 
Bob Farese and Aimee Kao
Tuesday, 4/21/2009
10-Noon
MB GH S261
Networks of Regional Vulnerability in FTD
Bill Seeley
Wed., 4/22/2009
1-3pm
MB GH S202
Tau and FTD
Lennart Mucke
Friday, 4/24/2009
10-Noon
MB GH S261
TDP-43, CHMP2B and microRNAs
Fen-Biao Gao
Monday, 4/27/2009
10-Noon
MB GH S261
Progranulin I
Bob Farese
Tuesday, 4/28/2009
10-Noon
MB GH S261
Progranulin II
Aimee Kao
Wed., 4/29/2009
1-3pm
MB GH S202
Microglia, inflammation and FTD
Li Gan
Friday, 5/1/2009
10-Noon
MB GH S261
Induced pluripotent stem (IPS) cells
Bob Farese
Monday, 5/4/2009
10-Noon
MB GH S261
Frontal lobe development
John Rubenstein
Tuesday, 5/5/2009
10-Noon
MB GH S261
Social dysregulation in FTD
Kate Rankin
Wed., 5/6/09
1-3pm
MB GH S261
Art and FTD
Bruce Miller
Friday, 5/8/2009
10-Noon
MB GH S261
Discuss Research Proposals
Bob Farese and Aimee Kao

Courses


Course Materials
(UCSF Access only)

4/20/09
Presentation

Scully, RE., et. al. NJEM. 2000

4/21/09
Presentation

Seeley, et. al. Neuron. 2009. 62:42-52


Borroni B., et. al. Rejuvenation Research. 2008. 11(3):585-595

4/22/09
Berger, Z., et. al. Journal of Neuroscience, 2007. 27:3650-3662

SantaCruz, K., et. al. Science, 2005. 309:476-481

Sahara, N., et. al. Curr Alzheimer Res, 2008. 5(6):591-8

4/24/09
Filimonenko, et. al. J Cell Biology, 2007. 179:485-500

Lee and Gao. BMB Reports, 2008. 41:827-832

Rademakers, et. al. Human Molec Genetics, 2008. 17:3631-3642

Igaz LM, et. al. Journal of Biological Chemistry, 2009. 284(13)8516-8524

4/27/09
Presentation

Baker, M., et. al. Nature, 2006. 442(7105)916-9

Van Damme, P., et. al. J Cell Biology, 2008. 181(1):37-41

Kayusaga, Y., et. al. Behav Brain Res, 2007. 185(2):110-8

4/28/09
Presentation

Guerra, RR., et. al. Growth Factors, 2007. 25(4):280-5

Lin, JH., et. al. Science, 2007. 318(5852):994-9

4/29/09
Presentation

Cardona, et. al. Nature Neuroscience 2006, 9:917-924

Stevens, et. al. Cell 2007, 131:1164-1178

5/1/09
Background reading:
Chamberlain, SJ, et. al. Neurogenetics, 2008. 9(4):227-35

Wernig, M. et. al. PNAS, 2008. 105(15):8586-61

Ebert, AD., et. al. Nature, 2009. 457(7227):277-80

5/4/09
Scearce-Levie, et. al. Genes, Brains and Behavior 2007, 7:344-354

Cholfin and Rubenstein. PNAS 104:7652-7657

5/5/09
Zahn, R. et. al. Brain 2009, epub ahead of print

NY Times Article

5/6/09
Seeley, WW. et. al. Brain, 2008. 131:39-49

NY Time Article

5/8/09