Neuroscience Graduate Program at UCSF
NS219 - Topics in Basic or Translational Neuroscience
(Mini Course)
Fronto-Temporal Dementia
Course Directors:
Bob Farese, email: bfarese@gladstone.ucsf.edu
Aimee Kao, email: aimeekao@gmail.com
First Class: Monday, April 20, 2009
See below for class schedule and locations.
Course Description:
This minicourse will explore the biology of frontotemporal dementia (FTD). FTD is the most common neurodegenerative disease in people under the age of 65, accounting for 15–20% of all dementia cases. This devastating disease is rapidly progressive and characterized by progressive neurodegeneration in the frontal and temporal lobes, often resulting in dramatic changes in behavior and personality. Insights into the molecular, cellular, and genetic bases of FTD are rapidly emerging. This course will cover broad aspects of FTD, ranging from the basic biology underlying the disease to clinical aspects, including ideas and approaches for therapies. The format will combine brief overview lectures, paper discussions, and the development of a brief and focused research plan.
Class Roster:
| Name | Program: |
| Newman, Heather | BMI |
| Varela, Rocco | BMI |
| Freeze, Ben | BMS |
| Petty, Lamar | CCB |
| Langseth, Abe | NS |
| Larkin, Paul | NS |
| Shen, Helen | NS |
| Moon, NyangMi "Amy" | BMS |
| Krater, Ian | BMS |
| Sahai, Pankaj | BMS |
| Chege, Sally | NS |
For your study list please use:
NS 219, 3 units, Director: Louis Reichardt, Grade option: S/U.
Class Schedule:
MB-Mission Bay
Date |
Time |
Location |
Class Topic |
Course Instructor |
Monday, 4/20/2009 |
10-Noon |
MB GH S261 |
Introduction to FTD |
Bob Farese and Aimee Kao |
Tuesday, 4/21/2009 |
10-Noon |
MB GH S261 |
Networks of Regional Vulnerability in FTD |
Bill Seeley |
Wed., 4/22/2009 |
1-3pm |
MB GH S202 |
Tau and FTD |
Lennart Mucke |
Friday, 4/24/2009 |
10-Noon |
MB GH S261 |
TDP-43, CHMP2B and microRNAs |
Fen-Biao Gao |
Monday, 4/27/2009 |
10-Noon |
MB GH S261 |
Progranulin I |
Bob Farese |
Tuesday, 4/28/2009 |
10-Noon |
MB GH S261 |
Progranulin II |
Aimee Kao |
Wed., 4/29/2009 |
1-3pm |
MB GH S202 |
Microglia, inflammation and FTD |
Li Gan |
Friday, 5/1/2009 |
10-Noon |
MB GH S261 |
Induced pluripotent stem (IPS) cells |
Bob Farese |
Monday, 5/4/2009 |
10-Noon |
MB GH S261 |
Frontal lobe development |
John Rubenstein |
Tuesday, 5/5/2009 |
10-Noon |
MB GH S261 |
Social dysregulation in FTD |
Kate Rankin |
Wed., 5/6/09 |
1-3pm |
MB GH S261 |
Art and FTD |
Bruce Miller |
Friday, 5/8/2009 |
10-Noon |
MB GH S261 |
Discuss Research Proposals |
Bob Farese and Aimee Kao |
Courses
Course Materials
(UCSF Access only)
4/20/09
Presentation
Scully, RE., et. al. NJEM. 2000
4/21/09
Presentation
Seeley, et. al. Neuron. 2009. 62:42-52
Borroni B., et. al. Rejuvenation Research. 2008. 11(3):585-595
4/22/09
Berger, Z., et. al. Journal of Neuroscience, 2007. 27:3650-3662
SantaCruz, K., et. al. Science, 2005. 309:476-481
Sahara, N., et. al. Curr Alzheimer Res, 2008. 5(6):591-8
4/24/09
Filimonenko, et. al. J Cell Biology, 2007. 179:485-500
Lee and Gao. BMB Reports, 2008. 41:827-832
Rademakers, et. al. Human Molec Genetics, 2008. 17:3631-3642
Igaz LM, et. al. Journal of Biological Chemistry, 2009. 284(13)8516-8524
4/27/09
Presentation
Baker, M., et. al. Nature, 2006. 442(7105)916-9
Van Damme, P., et. al. J Cell Biology, 2008. 181(1):37-41
Kayusaga, Y., et. al. Behav Brain Res, 2007. 185(2):110-8
4/28/09
Presentation
Guerra, RR., et. al. Growth Factors, 2007. 25(4):280-5
Lin, JH., et. al. Science, 2007. 318(5852):994-9
4/29/09
Presentation
Cardona, et. al. Nature Neuroscience 2006, 9:917-924
Stevens, et. al. Cell 2007, 131:1164-1178
5/1/09
Background reading:
Chamberlain, SJ, et. al. Neurogenetics, 2008. 9(4):227-35
Wernig, M. et. al. PNAS, 2008. 105(15):8586-61
Ebert, AD., et. al. Nature, 2009. 457(7227):277-80
5/4/09
Scearce-Levie, et. al. Genes, Brains and Behavior 2007, 7:344-354
Cholfin and Rubenstein. PNAS 104:7652-7657
5/5/09
Zahn, R. et. al. Brain 2009, epub ahead of print
NY Times Article
5/6/09
Seeley, WW. et. al. Brain, 2008. 131:39-49
NY Time Article
5/8/09