Neuroscience Graduate Program at UCSF
NS225 - Spring 2009
Neurobiology of Disease
Course Director: Steve Finkbeiner
E-mail: sfinkbeiner@gladstone.ucsf.edu
Prerequisite: NS201 or permission of the course director.
First Class: Monday, March 30, 2009
Classes are held Monday and Wednesday evenings from 6:00-8:30pm in Gladstone 107A/B, Mission Bay.
The Monday, May 25 class will be on Tuesday, May 26.
Attendance is expected (for those taking the course for credit).
Course Description:
This advanced course will provide an in-depth introduction to the mechanisms of some of the major neurological diseases that affect people. It will include lectures on aging, anxiety disorders, Alzheimer’s disease, autism, epilepsy, other episodic diseases of the nervous system (e.g., migraine, ataxias, etc…), Huntington’s disease and other triplet repeat disorders, sleep disorders, multiple sclerosis, Parkinson’s disease, and eye disorders.
Course Information Handout (PDF)
Course Materials:
Materials will be located at the right as they are added.
Class Schedule:
Date |
Time |
Location |
Lecturer |
Class Topic |
March/April |
||||
Monday, 3/30/09 |
6:00-8:30pm |
Gladstone 107A/B |
Louis Ptacek |
Channelopathies |
Wednesday, 4/1/09 |
6:00-8:30pm |
Gladstone 107A/B |
Louis Ptacek |
Channelopathies |
Monday, 4/6/09 |
6:00-8:30pm |
Gladstone 107A/B |
Cynthia Kenyon & Victor Valcour |
Aging |
Wednesday, 4/8/09 |
6:00-8:30pm |
Gladstone 107A/B |
Cynthia Kenyon & Victor Valcour |
Aging |
Monday, 4/13/09 |
6:00-8:30pm |
Gladstone 107A/B |
Robert Edwards & Anatol Kreitzer |
PD |
Wednesday, 4/15/09 |
6:00-8:30pm |
Gladstone 107A/B |
Robert Edwards & Anatol Kreitzer |
PD |
Monday, 4/20/09 |
6:00-8:30pm |
Gladstone 107A/B |
Michael Geschwind & Steven Finkbeiner |
HD |
Wednesday, 4/22/09 |
6:00-8:30pm |
Gladstone 107A/B |
Michael Geschwind & Steven Finkbeiner |
HD |
Monday, 4/27/09 |
6:00-8:30pm |
Gladstone 107A/B |
Lennart Mucke |
AD/FTD |
Wednesday, 4/29/09 |
6:00-8:30pm |
Gladstone 107A/B |
Lennart Mucke |
AD/FTD |
May |
||||
Monday, 5/4/09 |
6:00-8:30pm |
Gladstone 107A/B |
Larry Tecott |
Anxiety |
Wednesday, 5/6/09 |
6:00-8:30pm |
Gladstone 107A/B |
Larry Tecott |
Anxiety |
Monday, 5/11/09 |
6:00-8:30pm |
Gladstone 107A/B |
John Rubenstein |
Autism |
Wednesday, 5/13/09 |
6:00-8:30pm |
Gladstone 107A/B |
John Rubenstein |
Autism |
Monday, 5/18/09 |
6:00-8:30pm |
Gladstone 107A/B |
Ying-Hui Fu/Louis Ptacek |
Sleep/Sleep Disorders |
Wednesday, 5/20/09 |
6:00-8:30pm |
Gladstone 107A/B |
Ying-Hui Fu |
Sleep |
Monday, 5/25/09--No Class, UCSF Holiday |
||||
Tuesday, 5/26/09 |
6:00-8:30pm |
Gladstone 107A/B |
Stephen Hauser |
MS |
Wednesday, 5/27/09 |
6:00-8:30pm |
Gladstone 107A/B |
Stephen Hauser |
MS |
June |
||||
Monday, 6/1/09 |
6:00-8:30pm |
Gladstone 107A/B |
Scott Baraban & Daniel Lowenstein |
Epilepsy |
Wednesday, 6/3/09 |
6:00-8:30pm |
Gladstone 107A/B |
Scott Baraban & Daniel Lowenstein |
Epilepsy |
Monday, 6/8/09 |
6:00-8:30pm |
Gladstone 107A/B |
Doug Gould & Matt LaVail |
Eye disorders |
Wednesday, 6/10/09 |
6:00-8:30pm |
Gladstone 107A/B |
Doug Gould & Matt LaVail |
Eye disorders |
Thursday, 6/11/09 |
5:00pm-6:30pm |
Gladstone 107C |
Fen-Biao Gao |
Course Evaluation |
Courses
Course Materials
(UCSF Access Only)
March/April
3/30/09
4/1/09
4/6/09
4/8/09
4/13/09
Presentation-Edwards
4/15/09
4/20/09
4/22/09
4/27/09
General Review Papers
Mahley, RW., et. al. PNAS. 2006. 103(15):5644-5651
Palop, JJ., et. al. Nature. 2006. 443:768-773
Roberson, ED., et. al. Science. 2006. 314:781-784
Gotz, J. et. al. Nature Reviews Neuroscience. 2008. 9:532-544
Bezprozvanny, I. Science Signaling. 2009. 2:pe16
Cisse, M. et. al. Nature. 2009. 457:1090-1091
Palop, JJ. et. al. Arch. Neurol. 2009. 66(4):435-440
Seeley, WW. et. al. Neuron. 2009. 62:42-52
Alz. Facts and Figures 2009
4/29/09
Student Presentation Articles
Seeley, WW. et. al. Ann. Neurol. 2006. 60:660-667
Busche MA. et. al. Science. 2008. 321:1686-1689
Sanchez-Mejia, RO. et. al. Nature Neuroscience. 2008. 11(11):1311-1318
Moreno, H. et. al. PNAS. 2009. 106(14):5901-5906
May
5/4/09
5/6/09
5/11/09 & 5/13/09
Presentation
Reviews:
Rubenstein
Walsh
Discussion Paper:
Park
5/18/09
5/20/09
5/26/09
5/27/09
June
6/1/09
6/3/09
6/8/09
Edwards 2005 Science
Hageman 2001 Progress in retinal and eye research
Hageman 2005 Proc Natl Acad Sci USA
Haines 2005 Science
Hollyfield 2008 Nat Med
Howell-Libby JCB incl Suppl
Jakobs 2005 JCB
Klein 2005 Science
Libby 2005 PLoS Genet
6/10/09