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Neuroscience Graduate Program at UCSF

NS225 - Spring 2009

NS225 - Spring 2009
Neurobiology of Disease

Course Director: Steve Finkbeiner
E-mail: sfinkbeiner@gladstone.ucsf.edu

Prerequisite: NS201 or permission of the course director.

First Class: Monday, March 30, 2009
Classes are held Monday and Wednesday evenings from 6:00-8:30pm in Gladstone 107A/B, Mission Bay.
The Monday, May 25 class will be on Tuesday, May 26.
Attendance is expected (for those taking the course for credit).

Course Description:
This advanced course will provide an in-depth introduction to the mechanisms of some of the major neurological diseases that affect people. It will include lectures on aging, anxiety disorders, Alzheimer’s disease, autism, epilepsy, other episodic diseases of the nervous system (e.g., migraine, ataxias, etc…), Huntington’s disease and other triplet repeat disorders, sleep disorders, multiple sclerosis, Parkinson’s disease, and eye disorders.

Course Information Handout (PDF)

Course Materials:
Materials will be located at the right as they are added.

Class Schedule:

Date
Time
Location
Lecturer
Class Topic
March/April
Monday, 3/30/09
6:00-8:30pm
Gladstone 107A/B
Louis Ptacek
Channelopathies
Wednesday, 4/1/09
6:00-8:30pm
Gladstone 107A/B
Louis Ptacek
Channelopathies
Monday, 4/6/09
6:00-8:30pm
Gladstone 107A/B
Cynthia Kenyon & Victor Valcour
Aging
Wednesday, 4/8/09
6:00-8:30pm
Gladstone 107A/B
Cynthia Kenyon & Victor Valcour
Aging
Monday, 4/13/09
6:00-8:30pm
Gladstone 107A/B
Robert Edwards & Anatol Kreitzer
PD
Wednesday, 4/15/09
6:00-8:30pm
Gladstone 107A/B
Robert Edwards & Anatol Kreitzer
PD
Monday, 4/20/09
6:00-8:30pm
Gladstone 107A/B
Michael Geschwind & Steven Finkbeiner
HD
Wednesday, 4/22/09
6:00-8:30pm
Gladstone 107A/B
Michael Geschwind & Steven Finkbeiner
HD
Monday, 4/27/09
6:00-8:30pm
Gladstone 107A/B
Lennart Mucke
AD/FTD
Wednesday, 4/29/09
6:00-8:30pm
Gladstone 107A/B
Lennart Mucke
AD/FTD
May
Monday, 5/4/09
6:00-8:30pm
Gladstone 107A/B
Larry Tecott
Anxiety
Wednesday, 5/6/09
6:00-8:30pm
Gladstone 107A/B
Larry Tecott
Anxiety
Monday,  5/11/09
6:00-8:30pm
Gladstone 107A/B
John Rubenstein
Autism
Wednesday, 5/13/09
6:00-8:30pm
Gladstone 107A/B
John Rubenstein
Autism
Monday, 5/18/09
6:00-8:30pm
Gladstone 107A/B
Ying-Hui Fu/Louis Ptacek
Sleep/Sleep Disorders
Wednesday, 5/20/09
6:00-8:30pm
Gladstone 107A/B
Ying-Hui Fu
Sleep
Monday, 5/25/09--No Class, UCSF Holiday
Tuesday, 5/26/09
6:00-8:30pm
Gladstone 107A/B
Stephen Hauser
MS
Wednesday, 5/27/09
6:00-8:30pm
Gladstone 107A/B
Stephen Hauser
MS
June
Monday, 6/1/09
6:00-8:30pm
Gladstone 107A/B
Scott Baraban & Daniel Lowenstein
Epilepsy
Wednesday, 6/3/09
6:00-8:30pm
Gladstone 107A/B
Scott Baraban & Daniel Lowenstein
Epilepsy
Monday, 6/8/09
6:00-8:30pm
Gladstone 107A/B
Doug Gould & Matt LaVail
Eye disorders
Wednesday, 6/10/09
6:00-8:30pm
Gladstone 107A/B
Doug Gould & Matt LaVail
Eye disorders
Thursday, 6/11/09
5:00pm-6:30pm
Gladstone 107C
Fen-Biao Gao
Course Evaluation

 

Courses


Course Materials
(UCSF Access Only)

March/April

3/30/09

4/1/09

4/6/09

4/8/09

4/13/09
Presentation-Edwards

4/15/09

4/20/09

4/22/09

4/27/09
General Review Papers

Mahley, RW., et. al. PNAS. 2006. 103(15):5644-5651

Palop, JJ., et. al. Nature. 2006. 443:768-773

Roberson, ED., et. al. Science. 2006. 314:781-784

Gotz, J. et. al. Nature Reviews Neuroscience. 2008. 9:532-544

Bezprozvanny, I. Science Signaling. 2009. 2:pe16

Cisse, M. et. al. Nature. 2009. 457:1090-1091

Palop, JJ. et. al. Arch. Neurol. 2009. 66(4):435-440

Seeley, WW. et. al. Neuron. 2009. 62:42-52

Alz. Facts and Figures 2009

4/29/09
Student Presentation Articles

Seeley, WW. et. al. Ann. Neurol. 2006. 60:660-667

Busche MA. et. al. Science. 2008. 321:1686-1689

Sanchez-Mejia, RO. et. al. Nature Neuroscience. 2008. 11(11):1311-1318

Moreno, H. et. al. PNAS. 2009. 106(14):5901-5906


May

5/4/09

5/6/09

5/11/09 & 5/13/09
Presentation
Reviews:
Rubenstein
Walsh
Discussion Paper:
Park

5/18/09

5/20/09

5/26/09

5/27/09


June

6/1/09

6/3/09

6/8/09
Edwards 2005 Science

Hageman 2001 Progress in retinal and eye research

Hageman 2005 Proc Natl Acad Sci USA

Haines 2005 Science

Hollyfield 2008 Nat Med

Howell-Libby JCB incl Suppl

Jakobs 2005 JCB

Klein 2005 Science

Libby 2005 PLoS Genet

6/10/09