Neuroscience Graduate Program

Neuroscience Graduate Program at UCSF

NS222 - Fall 2008

NS222 - Fall 2008
Signaling in Neurobiology

Course Director: Louis Reichardt
E-mail: louis.reichardt@ucsf.edu

Prerequisite: NS201 or permission of the course director.

First Class: Thursday, October 2, 2008
Classes are held in GH S261, Mission Bay. (unless noted otherwise)
Please see schedule for dates and times.
Attendance is expected (for those taking the course for credit).

Course Description:
This course will discuss receptor-mediated signal transduction and its regulation at the cellular level. The first part of the course will be largely didactic, reviewing basic principles of information theory and molecular pharmacology that are relevant to all signaling systems. The second part of the course will focus on selected receptors and regulatory mechanisms that function in neurons. Faculty experts in each area will present a lecture and assign relevant research paper(s) for student discussion. Topics include G protein-coupled receptors and regulation, regulation of ion channel signaling, receptor tyrosine kinases, Wnt signaling, TGF-beta signaling, polarity and chemotaxis.

Course Materials:
Materials will be located at the right as they are added.

Class Schedule:

Date	Time	Location	Lecturer	Subject
October
Thurs. Oct. 2	5:30-7:30pm	MB GH S261	Mark von Zastrow	Signals and Noise
Tues. Oct. 7	5:30-7:30pm	MB GH S261	Mark von Zastrow	Dynamic Range and Adaptation
Thursday, October 9, 2008 - NO CLASS - Yom Kippur
Tues. Oct. 14	5:30-7:30pm	MB GH S261	Mark von Zastrow	Ultrasensitivity and Decisions
Thurs. Oct. 16	5:30-7:30pm	MB GH S271	Mark von Zastrow	Spatiotemporal Signaling
Mon. Oct. 20	6:15-8:15pm	MB GH S261	Mark von Zastrow	Receptor Theory
Wed. Oct. 22	5:30-7:30pm	MB GH S261	Mark von Zastrow	Molecular Pharmacology
Mon. Oct. 27	6:15-8:15pm	MB GH S261	Louis Reichardt	Calcium Signaling I
Wed. Oct. 29	5:30-7:30pm	MB GH S261	Louis Reichardt	Calcium Signaling II
November
Mon. Nov. 3	6:15-8:15pm	MB GH S261	Louis Reichardt	Calcium Signaling III
Wed. Nov. 5	5:30-7:30pm	MB GH S261	Susan Voglmaier & Louis Reichardt	Signaling Control of Presynaptic Function I Updated Reading list for 11/5 and 11/10
Mon. Nov. 10	6:15-8:15pm	MB GH S261	Susan Voglmaier & Louis Reichardt	Signaling Control of Presynaptic Function II
Wed. Nov. 12	5:30-7:30pm	MB GH S261	Louis Reichardt	Signaling Pathways that Control Postsynaptic Assembly. Actin Cytoskeleton and Cell Adhesion
November 17 and 19 - NO CLASS - SFN
Mon. Nov. 24	6:15-8:15pm	MB GH S261	Louis Reichardt	Signaling Pathways that Control Postsynaptic Assembly. Eph Receptors and Ephrins
Tues. Nov. 25	Class Canceled
November 26 - NO CLASS - Thanksgiving
December
Mon. Dec.1	6:15-8:15pm	MB GH S261	Louis Reichardt	Neurotrophin Signaling II. Roles at the Synapse
Wed. Dec. 3	5:30-7:30pm	MB GH S261	Graeme Davis & Louis Reichardt	Synaptic Scaling I
Mon. Dec. 8	6:15-8:15pm	MB GH S261	Graeme Davis & Louis Reichardt	Synaptic Scaling II
Wed. Dec. 10	5:30-7:30pm	MB GH S261	Louis Reichardt	Local Translation Control 1
Mon. Dec. 15	6:15-8:15pm	MB GH S261	Lily Jan & Louis Reichardt	Local Translation Control II
Wed. Dec. 17	5:30-7:30pm	MB GH S261	Lily Jan & Louis Reichardt	Local Translation Control III