| Lab Meetings 2001 | Meeting Contents |
January 9 |
Computational approaches to sensorimotor transformations ~sabes/LabMeeting/PougetSnyder2000.pdf Computational principles of movement neuroscience ~sabes/LabMeeting/WolpertGhahramani2000.pdf |
January 16 |
The plan is to work through a bunch of papers on reaching movement variability. There are four sets of papers: Soechting and Flanders, Gordon and Ghez, McIntyre and Lacquaniti, and Messier and Kalaska. Three people will each summarize (in 10 min or less) the data from one group. The rest of the meeting will be devoted to trying to understand the results. The meeting will be greatly improved if people who come have read most of the papers. Sam and I will each take one group. I'm looking for a volunteer to take the other two. First come, first served. Groups 1 & 2 are available on line and at ~sabes/LabMeeting. 1)Soechting JF, Flanders M. 2) Gordon J, Ghilardi MF, Ghez C. 3) This group is a bit more complicated, and may take more than 10 minutes (but no more than 15!) McIntyre J, Stratta F, Droulez J, Lacquaniti F. McIntyre J, Stratta F, Lacquaniti F. McIntyre J, Stratta F, Lacquaniti F. 4) Messier J, Kalaska JF. http://link.springerny.com/link/service/journals/00221/bibs/9125002/ Messier J, Kalaska JF. http://link.springerny.com/link/service/journals/00221/bibs/7115003/ |
January 23 |
After yesterday's brutal meeting, we'll take it light for next week. We'll read the Nature paper on the Minimum Variance model by Harris and Wolpert: Signal-dependent noise determines motor planning http://www.nature.com/cgitaf/DynaPage.taf?file=/nature/journal/v394/ |
January 30 |
This Tuesday we'll go back to cortex. We all know that parietal cortex does the visual work, sending a reach target to the frontal movement areas (PMd, M1, etc). But... here are two papers on sensory responses in frontal cortex: Shen L, Alexander GE * ~sabes/LabMeeting/ShenAlexander1997.pdf http://jn.physiology.org/cgi/content/full/77/3/1171 Boussaoud D, Wise SP * On my door Kurata, K; Hoshi, E. Reacquisition deficits in prism adaptation after Coding the Locations of Objects in the Dark |
February 6 |
Two papers on PMv, presented by Sam and Rob: Kurata, K; Hoshi, E. Reacquisition deficits in prism adaptation after Coding the Location of the Arm by Sight |
February 13 |
1) Kalaska JF. A review which includes most of the data from Crammond and Kalaska Cerebral Cortex 5(5) 410 (1995). 2) Read this abstract. The paper might be good too, and I encourage you to read it ;-). But the abstract may provide fuel for discussion of above. Exp Brain Res 1992;90(1):229-32 The effect of bilateral area 5 lesions on the analysis of proprioceptive information and the guidance of reaching movements was studied in three rhesus monkeys. In the first paradigm (Proprioceptive discrimination test) the monkeys were trained to discriminate between movements of a joystick to the right or left without visual control; they reported the direction of movement by touching or not touching a screen (go/no-go task). After area 5 had been removed, the monkeys were only mildly impaired on this test. It is concluded that such simple joint movement could be analysed in area 2, area 5 being concerned with more complex arm movements. In the second paradigm (Searching test) the monkey had to find a peanut on a board in the dark using proprioceptive information stored in memory during previous trials. After area 5 lesions, the number of correct reaches was not modified but the number of errors after an incorrect trial (correcting movement) was significantly increased. The data suggests that when visual input is not available, area 5 is involved in the guidance of arm movements on the basis of proprioceptive inputs. |
February 27 |
Continuing on with Area 5, a somewhat painful but influential paper on Area 5 (does the work "spherangular" ring a bell?): Representing Spatial Information For Limb Movement – |
March 6 |
As discussed last week, we'll continue with parietal cortex and reaching. Three papers: 1) Desmurget et al, 1999: The TMS paper we keep referring to. A good paper despite a few suspect authors. I believe Rob has agreed to present... Desmurget M, Epstein CM, Turner RS, Prablanc C, Alexander GE, ~sabes/LabMeeting/DesmurgetEtAl1999.pdf 2/3) The two Passingham papers on Parietal Lesions. M. F. S. Rushworth, P. D. Nixon, R. E. Passingham: http://link.springer-ny.com/link/service/journals/00221/bibs/7117002/71170292.htm M. F. S. Rushworth, P. D. Nixon, R. E. Passingham: http://link.springer-ny.com./link/service/journals/00221/tocs/t7117002.htm |
March 20 |
This week's lab meeting will be taking place, but it's going to be a "Real Lab Meeting". All are welcome, but it might be boring for those who don't consider themselves part of the lab and have no intention of considering themselves so in the future. We'll cover the following topics: 1) Short and medium term plans for the lab. I'll run through the main topics (Specific Aims) of the NIH grant We'll talk a little about the physiology plans. We'll talk about who wants to do what in the short/medium term (i.e. between now and end-of-summer?) 2) The lab meetings Future reading topics 3) A few administrative items regarding the two lab spaces. |
March 27 |
Caminiti et al Galletti et al |
April 10 |
Next Tuesday (4/10), we'll begin our overview of cortical sensorimotor areas. Sam, Katrin, and I will begin with Parietal Cortex, including: V6, V6a, MIP, PEa, VIP, LIP, AIP, 7a, 7b, 7m, and MDP. |
April 17 |
* Somatosensory Areas -- Dave Largely segregated parietofrontal connections linking rostral http://link.springer-ny.com./link/service/journals/00221/bibs/9128001/91280181.htm Also, I highly recommend looking at PubMed with a search like: "parietal[TW] AND 7b[TW]" for your brain area. The search above yielded an excellent list of all the old papers. (in case you care, [TW] is text word, i.e. works for title or abstract) Schenk on the Medial wall Here are the motor papers to read in preparation for Friday. 1) Meyer, Abrams, Kornblum, Wright, and Smith, "Optimality in Human Motor 2) TTodorov, "Cosine Tuning Minimizes Motor Errors". |
April 24 |
We'll continue this Tuesday, 3pm, wrapping up parietal cortex |
May 5 |
Finally finishing Parietal Cortex, Chris Moore and I will present. Presented by Sabes, Sober and Schenk: Presented by McGonigle and Moore : Presented by Rob and Steve: |
May 15 |
The next Sabes Lab Meeting will take place tomorrow, 3pm. Rob will cover the supplementary motor areas, and Stephanie and Clint will start in on M1. |
May 22 |
1) Developmental time course (critical period) of prism-adaptation plasticity: Knudsen, EI; Knudsen, PF. Sensitive and critical periods for 2) Early paper on an underlying neural mechanism: ~sam/Lab_Meeting_Papers/Brainard_Knudsen_91.pdf Knudsen, EI; Brainard, MS. Visual instruction of the neural map |
May 29 |
Contrary to last week's plans, we will meet tomorrow 3pm for a summer organizational meeting. Topics include summer research priorities, plans for the two labs, and introducing our summer undergrad RA, who will be arriving tomorrow morning. We will return to the Knudsen Owl work for one more meeting next week. Zheng, W; Knudsen, EI. Functional selection of adaptive auditory space http://www.sciencemag.org/cgi/content/full/284/5416/962 review for background: Knudsen, EI; Zheng, W; DeBello, WM. Traces of learning in the auditory |
June 5 |
Paper for lab meeting this week: Zheng, W; Knudsen, EI. Functional selection of adaptive auditory space http://www.sciencemag.org/cgi/content/full/284/5416/962 review for background: Knudsen, EI; Zheng, W; DeBello, WM. Traces of learning in the auditory |
June 12 |
A pair of new papers from Caminiti explores areas V6a and PEc/MDP/medial-SPL-wall, their connectivity with PMd, and their role in Eye Hand coordination. A potentially nice pair of anatomy and physiology papers. Eye-Hand Coordination during Reaching. I. Anatomical Relationships between Parietal and Frontal Cortex. http://cercor.oupjournals.org/cgi/content/full/11/6/513 Eye-Hand Coordination during Reaching. II. An Analysis of the Relationships between Visuomanual Signals in Parietal Cortex and Parieto-frontal Association Projections. |
June 19 |
Clower DM, Hoffman JM, Votaw JR, Faber TL, Woods RP, Alexander GE. "Neuronal Correlates of Sensorimotor Adaptation", Chp 4 of Dottie's thesis |
June 26 |
1) The recent Bizzi paper, looking at M1: Neuron 2001 May;30(2):593-607 2) Supplementary to (1) (i.e. not required reading), an older paper on the same topic: Proc Natl Acad Sci U S A 2000 Feb 29;97(5):2259-63 http://www.pnas.org/cgi/content/full/97/5/2259 3) An odd Shadmehr looking at EMG "correlates": J Neurosci 1999 Oct 1;19(19):8573-88 |
July 3 |
We'll read the three van Donkelaar papers on Eye-Hand coordination. Katrin agreed to present (1), and Tory and Dan agreed to take (2) and (3). I've given the URL's for the two which are freely available, but all three can be found at http://keck.ucsf.edu/~sabes/LabMeeting/ 1) Transcranial Magnetic Stimulation Disrupts Eye-Hand Interactions in the http://jn.physiology.org/cgi/reprint/84/3/1677.pdf 2) Eye-hand coordination to visual versus remembered targets. http://link.springer-ny.com/link/service/journals/00221/papers/0133003/01330414.pdf 3) Saccade amplitude influences pointing movement kinematics. |
July 10 |
The next lab meeting will be Tues at 3pm. We are going to have a mini-symposium on the Superior Colliculus with an emphasis on its role in integrating sensory and motor modalities. The following week, we'll be reading newer (less well established) work which explores the role of SC in arm movements (arm saccades?!). 1) Katrin will discuss an older, classic review by Sparks, which focuses on saccadic eye movements: Sparks DL. 2) I'll have few words to say about the book "The Merging of the Senses" by Stein and Meredith, which (as the name implies) emphasises sensory integration aspects of SC function. Maybe available in the library. 3) We'll also hear about some recent work from Sparks' lab showing the saccadic eye movement activity in the SC is probably better thought of as gaze saccade activity, i.e. for coordinated movement of the eye and head. Sam, Tory, Dan, and/or Yigal will present two or three of the following, in any order or combination which they agree upon: a) behavior: Edward G. Freedman and David L. Sparks http://jn.physiology.org/cgi/reprint/77/5/2328.pdf b) physiology: Edward G. Freedman and David L. Sparks http://jn.physiology.org/cgi/reprint/78/3/1669.pdf c) more recent review: Sparks DL. http://keck.ucsf.edu/~sabes/LabMeeting/Sparks1999.pdf |
July 17 |
Superior Colliculus and Reaching, some new(ish) results. And Sam was right, reticular formation lies beneath SC. Exp Brain Res. 1997 Jun;115(2):191-205. http://link.springerny.com/link/service/journals/00221/papers/7115 Exp Brain Res 1997 Jun;115(2):206-16 http://link.springerny.com/link/service/journals/00221/papers/7115 A short paper showing some nice temporal correlation between SC and EMG, suggesting a fairly tight linkage. J Neurophysiol 1999 Apr;81(4):1978-82 http://jn.physiology.org/cgi/reprint/81/4/1978.pdf Additional food for thought (not required reading, won't be presented) A) An earlier paper suggesting where the above signal might come from: Behav Brain Res 1985 Nov-Dec;18(2):95-105 In retrograde studies of corticotectal projections in the monkey using horseradish peroxidase (HRP), projections of the frontal lobes were found to originate not only from the frontal eye fields and prefrontal association cortex but also from both motor and premotor cortex. Even small HRP injections into the superficial layers of the superior colliculus yielded labelled cells in the agranular cortex (area 6) of the anterior bank of the arcuate sulcus. After large collicular injections affecting all layers, labelled cells were found in both motor and premotor cortex. This projection appeared to be topographically organized. Injections into the anterolateral parts of the superior colliculus labelled cells that were distributed within the presumed finger-hand--arm-shoulder representation, whereas after more caudal injections labelled cells occurred more in the presumed arm-trunk representation. The supplementary motor cortex was not found to contain labelled cells. The corticotectal cells in the motor cortex differed from those in the premotor cortex in their size distribution; the former being small, the latter both small and large. The functional significance of the motor and premotor input into the superior colliculus for sensory, and particularly visual, guidance of movements is discussed in view of a collicular role in the extrapersonal space representation and of its possible participation in steering arm and hand movements. B) A recent paper on coding -- some cells look like motor only, some show strong gaze dependent effects. J Neurophysiol 2000 Mar;83(3):1283-99 |
July 24 |
1) E. E. Fetz and P. D. Cheney, 2) D. Flament, P. A. Fortier and E. E. Fetz, 3) Matsumura et. al. Available on Fetz's web page http://depts.washington.edu/pbiopage/faculty/fetz.html And one Lemon paper, 4) K. M. Bennett and R. N. Lemon, |
October 2 |
Let's meet this coming Tuesday at 3:30 (the new lab meeting time for this term) to talk over plans for the fall. I'll bring refreshments. |
November 27 |
We'll begin with a review of highlights from the Neuroscience Meeting. Then we'll focus on one of them: Emanuel Todorov's new ideas on optimal feedback control. He's got two papers on the topic, a methods paper, which I'm trying to get hold of, and results paper. The two Todorov papers can be downloaded at: |
December 18 |
Ojakangas, CL; Ebner, TJ. Purkinje cell complex spike activity European Journal of Neuroscience 10 (1) 86-94 European Journal of Neuroscience 10 (1) 95-105 Another modeling paper by people I'm even more suspect of is below... Another model for the future possibly.... http://www.learnmem.org/content/vol3/issue6/ A Neural Model of Cerebellar Learning for Arm Movement Control: JL Contreras-Vidal, S Grossberg and D Bullock A neural network model of opponent cerebellar learning for arm movement control is proposed. The model illustrates how a central pattern generator in cortex and basal ganglia, a neuromuscular force controller in spinal cord, and an adaptive cerebellum cooperate to reduce motor variability during multijoint arm movements using mono-and bi-articular muscles. Cerebellar learning modifies velocity commands to produce phasic antagonist bursts at interpositus nucleus cells whose feed-forward action overcomes inherent limitations of spinal feedback control of tracking. Excitation of alpha motoneuron pools, combined with inhibition of their Renshaw cells by the cerebellum, facilitate movement initiation and optimal execution. Transcerebellar pathways are opened by learning through long-term depression (LTD) of parallel fiber-Purkinje cell synapses in response to conjunctive stimulation of parallel fibers and climbing fiber discharges that signal muscle stretch errors. The cerebellar circuitry also learns to control opponent muscles pairs, allowing cocontraction and reciprocal inhibition of muscles. Learning is stable, exhibits load compensation properties, and generalizes better across movement speeds if motoneuron pools obey the size principle. The intermittency of climbing fiber discharges maintains stable learning. Long-term potentiation (LTP) in response to uncorrelated parallel fiber signals enables previously weakened synapses to recover. Loss of climbing fibers, in the presence of LTP, can erode normal opponent signal processing. Simulated lesions of the cerebellar network reproduce symptoms of cerebellar disease, including sluggish movement onsets, poor execution of multijoint plans, and abnormally prolonged endpoint oscillations. Received February 14,1997; accepted in revised form April 14, 1997. From sabes@phy.ucsf.edu Wed Oct 16 14:55:45 2002 *********AND WERE THEY TERRIBLE OR WERE THEY PRESENTED? Sam, European Journal of Neuroscience 10 (1) 86-94 European Journal of Neuroscience 10 (1) 95-105 |